Antibiotics Antivirals Library Chemical Structure : TP0586532 CAS No.: 2427584-96-9 聽 TP0586532 (TP 0586532) Catalog No.: URK-V603聽聽Only Used For Lab. TP0586532 (TP 0586532) is a novel non-hydroxamate inhibitor of UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with IC50 of 0.101 uM, shows MIC values 2 mg/mL and 4 mg/mL for E. coli ATCC 25922 and K. pneumoniae ATCC 13883. 聽 Biological Activity TP0586532 (TP 0586532) is a novel non-hydroxamate inhibitor of UDP-3-O-acyl-N--acetylglucosamine deacetylase (LpxC) with IC50 of 0.101 uM, shows MIC values 2 mg/mL and 4 mg/mL for E. coli ATCC 25922 and K. pneumoniae ATCC 13883; TP0586532 is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk. The MIC90 of TP0586532 against clinical isolates of carbapenem-resistant Klebsiella pneumoniae was 4 ug/mL. TP0586532 also showed an in vivo efficacy against murine systemic, urinary tract and lung infection models caused by meropenem- or ciprofloxacin-resistant strains. TP0586532 also reduces LPS release and IL-6 production both in vitro and in vivo. 聽 Physicochemical Properties M.Wt560.534 FormulaC26H28N4O4 CAS No.2427584-96-9 StorageSolide Powder -20 掳C 3years; 4掳C 2yearsIn Solvent -80掳C 6 Months -20掳C 1 Months Solubility聽 Chemical Name聽聽 References 1. Ushiyama F, et al. Bioorg Med Chem. 2021 Jan 15;30:115964. 2. Fujita K, et al. J Antibiot (Tokyo). 2022 Feb;75(2):98-107. 3. Fujita K, et al. J Antibiot (Tokyo). 2022 Mar;75(3):136-145. URK-V603_COA URK-V603_SDS URK-V603_TDS 聽 Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use! 聽Antibiotics Antivirals Library website:http://www.ureiko-chem.com/inhibitors-agonists/antibiotics-antivirals-library/